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Monitor Intently (1)pentobarbital will reduce the extent or result of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or outcome of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with strong CYP3A4 inducers will not